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Neural mechanisms supporting maladaptive food choices in anorexia nervosa

Nature Neuroscience volume 18, pages 15711573 (2015) | Download Citation

Abstract

People routinely make poor choices, despite knowledge of negative consequences. The authors found that individuals with anorexia nervosa, who make maladaptive food choices to the point of starvation, engaged the dorsal striatum more than healthy controls when making choices about what to eat, and that activity in fronto-striatal circuits was correlated with their actual food consumption in a meal the next day.

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Acknowledgements

We thank J. Schebendach for guidance and support for the laboratory meals and nutritional analyses. This research was supported in part by the Global Foundation for Eating Disorders and the US National Institute for Mental Health (R01 MH079397, K23 MH076195).

Author information

Author notes

    • Karin Foerde
    •  & Joanna E Steinglass

    These authors contributed equally to this work.

    • Daphna Shohamy
    •  & B Timothy Walsh

    These authors jointly directed this work.

Affiliations

  1. Psychology Department, New York University, New York, New York, USA.

    • Karin Foerde
  2. Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, New York, USA.

    • Karin Foerde
    • , Joanna E Steinglass
    •  & B Timothy Walsh
  3. Department of Psychiatry, Columbia University Medical Center, New York, New York, USA.

    • Joanna E Steinglass
    •  & B Timothy Walsh
  4. Department of Psychology, Zuckerman Mind Brain Behavior Institute, and Kavli Institute for Brain Science, Columbia University, New York, New York, USA.

    • Daphna Shohamy

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Contributions

K.F., J.E.S., D.S. and B.T.W. designed the research. J.E.S. collected the data. K.F. and J.E.S. analyzed the data. K.F., J.E.S., D.S. and B.T.W. wrote the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Karin Foerde or Joanna E Steinglass.

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DOI

https://doi.org/10.1038/nn.4136

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