Uhlén, M. et al. Science 347, 1260419 (2015).

Uhlén et al. present a near-complete map of the human tissue proteome. This comprehensive map, covering all major organs and tissues in the human body and 90% of all putative protein-coding genes, was constructed using quantitative transcriptome profiling data from RNA sequencing and protein profiling data from tissue microarray–based immunohistochemistry. The analysis revealed that almost half of all protein-coding genes are expressed in all tissues, suggesting that these proteins are responsible for 'housekeeping' functions. The researchers also examined global traits of the secretome, membrane proteome, regulatory proteome, isoform proteome, cancer proteome and druggable proteome. All of the data are available in a free, interactive web resource as part of the Human Protein Atlas (http://www.proteinatlas.org/), which should be a valuable tool for studying both basic human biology and disease.