Databases

Definition

A database is one or more sets of data, for example numbers, characters and images, bundled together with software that enables data to be added, removed or retrieved. Databases can be used to store research data, for example in protein databases and genetic databases, and they organise data into standard formats so that information can readily be obtained.

Latest Research and Reviews

  • Reviews |

    For clinical cases of Mendelian disease that lack a genetic diagnosis, genome and exome sequencing are increasingly used for seeking the genetic cause. This Review discusses the strategies and computational tools for prioritizing the many genetic variants identified in each genome into those that are most likely to be causal for disease. The authors discuss how diverse types of biochemical, evolutionary, pedigree and clinical-phenotype information are used, and they highlight common pitfalls to be aware of for responsible variant prioritization.

    • Karen Eilbeck
    • , Aaron Quinlan
    •  & Mark Yandell
  • Research | | open

    Standards for sequencing the microbial 'uncultivated majority', namely bacterial and archaeal single-cell genome sequences, and genome sequences from metagenomic datasets, are proposed.

    • Robert M Bowers
    • , Nikos C Kyrpides
    • , Ramunas Stepanauskas
    • , Miranda Harmon-Smith
    • , Devin Doud
    • , T B K Reddy
    • , Frederik Schulz
    • , Jessica Jarett
    • , Adam R Rivers
    • , Emiley A Eloe-Fadrosh
    • , Susannah G Tringe
    • , Natalia N Ivanova
    • , Alex Copeland
    • , Alicia Clum
    • , Eric D Becraft
    • , Rex R Malmstrom
    • , Bruce Birren
    • , Mircea Podar
    • , Peer Bork
    • , George M Weinstock
    • , George M Garrity
    • , Jeremy A Dodsworth
    • , Shibu Yooseph
    • , Granger Sutton
    • , Frank O Glöckner
    • , Jack A Gilbert
    • , William C Nelson
    • , Steven J Hallam
    • , Sean P Jungbluth
    • , Thijs J G Ettema
    • , Scott Tighe
    • , Konstantinos T Konstantinidis
    • , Wen-Tso Liu
    • , Brett J Baker
    • , Thomas Rattei
    • , Jonathan A Eisen
    • , Brian Hedlund
    • , Katherine D McMahon
    • , Noah Fierer
    • , Rob Knight
    • , Rob Finn
    • , Guy Cochrane
    • , Ilene Karsch-Mizrachi
    • , Gene W Tyson
    • , Christian Rinke
    • , The Genome Standards Consortium
    • , Nikos C Kyrpides
    • , Lynn Schriml
    • , George M Garrity
    • , Philip Hugenholtz
    • , Granger Sutton
    • , Pelin Yilmaz
    • , Folker Meyer
    • , Frank O Glöckner
    • , Jack A Gilbert
    • , Rob Knight
    • , Rob Finn
    • , Guy Cochrane
    • , Ilene Karsch-Mizrachi
    • , Alla Lapidus
    • , Folker Meyer
    • , Pelin Yilmaz
    • , Donovan H Parks
    • , A M Eren
    • , Lynn Schriml
    • , Jillian F Banfield
    • , Philip Hugenholtz
    •  & Tanja Woyke
    Nature Biotechnology 35, 725–731

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