An in vitro RNA-labeling technique with single-molecule resolution offers a look into the kinetics and the location of splicing.
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References
Raj, A. et al. Imaging individual mRNA molecules using multiple singly labeled probes. Nat. Methods 5, 877–879 (2008).
Vargas, D.Y. et al. Single-molecule imaging of transcriptionally coupled ad uncoupled splicing. Cell 147, 1054–1065 (2011).
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Rusk, N. Timing an intron's departure. Nat Methods 9, 122–123 (2012). https://doi.org/10.1038/nmeth.1882
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DOI: https://doi.org/10.1038/nmeth.1882