A new potential breast cancer oncogene, ZNF703, has been identified in the chromosomal region 8p12 in humans, which is commonly amplified in an aggressive subtype of breast cancer. ZNF703 is a transcriptional repressor and regulates many genes that are involved in multiple aspects of the cancer phenotype, such as increased proliferation, invasion and an altered balance of progenitor stem cells.
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Spellman, P., Gray, J. A new treasure in the breast cancer gene hunt. Nat Med 17, 422–423 (2011). https://doi.org/10.1038/nm0411-422
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DOI: https://doi.org/10.1038/nm0411-422