This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway
Journal of Translational Medicine Open Access 19 October 2016
-
Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance
Genome Biology Open Access 30 August 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Murtaza, M. et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 497, 108–112 (2013).
Schwarzenbach, H., Hoon, D.S. & Pantel, K. Cell-free nucleic acids as biomarkers in cancer patients. Nat. Rev. Cancer 11, 426–437 (2011).
Pantel, K., Brakenhoff, R.H. & Brandt, B. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat. Rev. Cancer 8, 329–340 (2008).
Heitzer, E. et al. Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Res. 73, 2965–2975 (2013).
Baccelli, I. et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat. Biotechnol. advance online publication, http://dx.doi.org/10.1038/nbt.2576 (2013).
Mandel, P. & Metais, P. Les acides nucleiques du plasma sanguin chez l'homme. C.R. Seances Soc. Biol. Fil. 142, 241–243 (1948).
Diehl, F. et al. Circulating mutant DNA to assess tumor dynamics. Nat. Med. 14, 985–990 (2008).
Diehl, F. et al. Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc. Natl. Acad. Sci. USA 102, 16368–16373 (2005).
Dawson, S.J. et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N. Engl. J. Med. 368, 1199–1209 (2013).
Diaz, L.A. Jr. et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486, 537–540 (2012).
Leary, R.J. et al. Development of personalized tumor biomarkers using massively parallel sequencing. Sci. Transl. Med. 2, 20ra14 (2010).
Leary, R.J. et al. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci. Transl. Med. 4, 162ra154 (2012).
Chan, K.C. et al. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clin. Chem. 59, 211–224 (2013).
Forshew, T. et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci. Transl. Med. 4, 136ra168 (2012).
Ethics declarations
Competing interests
L.D. is a cofounder of Personal Genome Diagnostics and Inostics, is a member of their scientific advisory boards and owns stock in both companies, which is subject to certain restrictions under Johns Hopkins University policy. The other authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Tracking tumor resistance using 'liquid biopsies'. Nat Med 19, 676–677 (2013). https://doi.org/10.1038/nm.3233
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3233
This article is cited by
-
Toward platelet transcriptomics in cancer diagnosis, prognosis and therapy
British Journal of Cancer (2022)
-
Identification of mutant K-RAS in pituitary macroadenoma
Pituitary (2021)
-
Tumour heterogeneity: principles and practical consequences
Virchows Archiv (2016)
-
Pathologists and liquid biopsies: to be or not to be?
Virchows Archiv (2016)
-
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway
Journal of Translational Medicine (2016)