The sirtuins (SIRTs) have gained preeminence for their roles in the response to caloric restriction and the regulation of aging and lifespan. A new study now identifies gene promoters that bind the transcription factor AP1 as targets for silencing by SIRT6, providing possible links between SIRT6 deficiency and dysregulation of insulin-like growth factor signaling, hypertrophic cardiomyopathy and heart failure (pages 1643–1650).
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Webster, K. A sirtuin link between metabolism and heart disease. Nat Med 18, 1617–1619 (2012). https://doi.org/10.1038/nm.2983
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DOI: https://doi.org/10.1038/nm.2983
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