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PDGF-B exploits stromal EPO

Nature Medicine volume 18, pages 22–24 (2012)Cite this article

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A new study in mice shows that platelet-derived growth factor-B (PDGF-B) boosts tumor growth by exerting a double function after induction of erythropoietin (EPO) expression from stromal components—a proangiogeneic response in the endothelium and hematopoietic stimulation (pages 100–110).

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Figure 1: Proposed paracrine and systemic actions of tumor-derived PDGF-B that promote tumor growth.

Katie Vicari

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Authors and Affiliations

  1. Hematology Division, Lisa M. McGinnis and Calvin J. Kuo are at the Stanford University School of Medicine, Stanford, California, USA.,

    Lisa M McGinnis & Calvin J Kuo

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  1. Lisa M McGinnis
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  2. Calvin J Kuo
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Correspondence to Calvin J Kuo.

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The authors declare no competing financial interests.

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McGinnis, L., Kuo, C. PDGF-B exploits stromal EPO. Nat Med 18, 22–24 (2012). https://doi.org/10.1038/nm.2623

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