The 'choice' between the CD4+CD8− and CD4−CD8+ T cell lineage involves genomic specification via a set of transcription factors. A new study shows that the zinc-finger protein MAZR is another member of this transcription factor network.
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Transcriptional control of CD4 and CD8 coreceptor expression during T cell development
Cellular and Molecular Life Sciences Open Access 21 June 2013
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Takada, K., Takahama, Y. Another zinc finger in the pie of CD4-CD8 lineage choice. Nat Immunol 11, 370–371 (2010). https://doi.org/10.1038/ni0510-370
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DOI: https://doi.org/10.1038/ni0510-370
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Transcriptional control of CD4 and CD8 coreceptor expression during T cell development
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