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STAT5 alters the state of transcriptional networks, driving aggressive leukemia

Nature Immunology volume 18, pages 597–598 (2017)Cite this article

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The transcription factor STAT5 acts as an oncoprotein in B cell acute lymphoblastic leukemia, competing with the transcription factors NF-κB and Ikaros for binding to DNA.

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Figure 1: STAT5 in aggressive leukemia.

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Authors and Affiliations

  1. Sinisa Dovat is in the Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.,

    Sinisa Dovat

  2. Kimberly J. Payne is in the Department of Pathology and Human Anatomy, Loma Linda University, Loma Linda, California, USA.,

    Kimberly J Payne

Authors
  1. Sinisa Dovat
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  2. Kimberly J Payne
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Correspondence to Sinisa Dovat or Kimberly J Payne.

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Competing interests

K.J.P. has patent applications related to the treatment of B-ALL and is the founder of Elf Zone, a company that develops cancer therapeutics and tools for cancer research.

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Dovat, S., Payne, K. STAT5 alters the state of transcriptional networks, driving aggressive leukemia. Nat Immunol 18, 597–598 (2017). https://doi.org/10.1038/ni.3747

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