The Pyrin inflammasome guard is disabled if the activity of small cellular GTPase is compromised in response to defects in the mevalonate pathway and is disabled directly by mutations in the gene encoding Pyrin, which results in the interleukin 1β (IL-1β)-driven autoinflammatory diseases MKD and FMF.
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Dorfleutner, A., Stehlik, C. A dRAStic RHOAdblock of Pyrin inflammasome activation. Nat Immunol 17, 900–902 (2016). https://doi.org/10.1038/ni.3511
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DOI: https://doi.org/10.1038/ni.3511
