The thymic development of CD8+ T cells requires the presentation of different sets of peptides on major histocompatibility complex class I for positive selection and negative selection.
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Brzostek, J., Gascoigne, N. Vive la peptide différence!. Nat Immunol 17, 896–898 (2016). https://doi.org/10.1038/ni.3507
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DOI: https://doi.org/10.1038/ni.3507