Central tolerance

Definition

Central tolerance encompasses the mechanisms that render newly developing lymphocytes in primary lymphoid organs tolerant to self antigens. Developing B cells and T cells that react strongly to self antigens either undergo alteration of their antigen receptors, or face functional inactivation, deletion by apoptosis or programming into a suppressive phenotype.

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News and Comment

  • News and Views |

    Caveolin-1 has a critical role in orchestrating the membrane organization of B cells. In its absence, signaling via the B cell antigen receptor and B cell tolerance are impaired, which results in autoimmunity.

    • Julie Zikherman
    •  & Clifford A Lowell
    Nature Immunology 18, 1065–1066
  • News and Views |

    The thymic development of CD8+ T cells requires the presentation of different sets of peptides on major histocompatibility complex class I for positive selection and negative selection.

    • Joanna Brzostek
    •  & Nicholas R J Gascoigne
    Nature Immunology 17, 896–898
  • News and Views |

    Thymic selection shapes the repertoire of potentially autoreactive thymocytes that are allowed to mature. The expression pattern of self antigen seen by thymocytes determines the number and functional ability of autoreactive T cells.

    • Douglas G Millar
    •  & Pamela S Ohashi
    Nature Immunology 17, 115–116