Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TREML4 adds fuel to the TLR7 fire

Nature Immunology volume 16, pages 445–446 (2015)Cite this article

Subjects

The cell-surface receptor TREML4 amplifies cellular responses to single-stranded RNA by regulating recruitment of the adaptor MyD88 to the receptor TLR7. Mice lacking TREML4 show impaired antiviral immunity but also reduced severity of lupus-like disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Amplification of TLR7 signaling by TREML4.

Katie Vicari/Nature Publishing Group

References

  1. Ramirez-Ortiz, Z.G. et al. Nat. Immunol. 16, 495–504 (2015).

    Article  CAS  Google Scholar 

  2. Means, T.K. et al. J. Clin. Invest. 115, 407–417 (2005).

    Article  CAS  Google Scholar 

  3. Baccala, R., Hoebe, K., Kono, D.H., Beutler, B. & Theofilopoulos, A.N. Nat. Med. 13, 543–551 (2007).

    Article  CAS  Google Scholar 

  4. Christensen, S.R. et al. Immunity 25, 417–428 (2006).

    Article  CAS  Google Scholar 

  5. Pisitkun, P. et al. Autoreactive Science 312, 1669–1672 (2006).

    CAS  PubMed  Google Scholar 

  6. Hemmi, H . et al. J. Immunol. 182, 1278–1286 (2009).

    Article  CAS  Google Scholar 

  7. Hemmi H . et al. J. Immunol. 188, 1147–1155 (2012).

    Article  CAS  Google Scholar 

  8. Idoyaga, J. et al. J. Clin. Invest. 123, 844–854 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Washington, A.V. et al. J. Clin. Invest. 119, 1489–1501 (2009).

    Article  CAS  Google Scholar 

  10. Delgado, M.A., Elmaoued, R.A., Davis, A.S., Kyei, G. & Deretic, V. EMBO J. 27, 1110–1121 (2008).

    Article  CAS  Google Scholar 

  11. Guiducci, C. et al. J. Exp. Med. 207, 2931–2942 (2010).

    Article  CAS  Google Scholar 

  12. Chen, D.Y. et al. Arthritis Res. Ther. 15, R39 (2013).

    Article  CAS  Google Scholar 

  13. Dominguez-Villar, M., Gautron, A.S., de Marcken, M., Keller, M.J. & Hafler, D.A. Nat. Immunol. 16, 118–128 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mihai G. Netea and Frank L. van de Veerdonk are in the Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.,

    Mihai G Netea & Frank L van de Veerdonk

Authors
  1. Mihai G Netea
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Frank L van de Veerdonk
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Mihai G Netea or Frank L van de Veerdonk.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Netea, M., van de Veerdonk, F. TREML4 adds fuel to the TLR7 fire. Nat Immunol 16, 445–446 (2015). https://doi.org/10.1038/ni.3149

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3149

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing