Abstract
Therapies that target molecular pathways do not provide uniform benefits for all patients at present. New transformative therapies for autoimmune and inflammatory diseases require greater molecular understanding of patient subsets and the ability to personalize targeted therapies for each subset.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance: development of other autoantibodies and progression to type 1 diabetes
Diabetologia Open Access 16 December 2015
-
Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity
Nature Communications Open Access 06 August 2014
-
Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics
Arthritis Research & Therapy Open Access 30 April 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
National Asthma Education and Prevention Program. J. Allergy Clin. Immunol. 120(5 Suppl.), S94–S138 (2007).
Capdeville, R., Buchdunger, E., Zimmermann, J. & Matter, A. Nat. Rev. Drug Discov. 1, 493–502 (2002).
Amado, R.G., et al. J. Clin. Oncol. 26, 1626–1634 (2008).
Wenzel, S.E. Nat. Med. 18, 716–725 (2012).
Moffatt, M.F. et al. N. Engl. J. Med. 363, 1211–1221 (2010).
Woodruff, P.G. et al. Am. J. Respir. Crit. Care Med. 180, 388–395 (2009).
Corren, J. et al. N. Engl. J. Med. 365, 1088–1098 (2011).
Navarra, S.V. et al. Lancet 377, 721–731 (2011).
Furie, R. et al. Arthritis Rheum. 63, 3918–3930 (2011).
Stohl, W. et al. Arthritis Rheum. 64, 2328–2337 (2012).
Santiago-Raber, M.L. et al. J. Exp. Med. 197, 777–788 (2003).
Baechler, E.C. et al. Proc. Natl. Acad. Sci. USA 100, 2610–2615 (2003).
Bennett, L. et al. J. Exp. Med. 197, 711–723 (2003).
Kirou, K.A. et al. Arthritis Rheum. 52, 1491–1503 (2005).
Imielinski, M. et al. Nat. Genet. 41, 1335–1340 (2009).
Sokol, H. & Seksik, P. Curr. Opin. Gastroenterol. 26, 327–331 (2010).
Sandborn, W.J. et al. Gastroenterology 135, 1130–1141 (2008).
Targan, S.R. et al. N. Engl. J. Med. 337, 1029–1035 (1997).
Hanauer, S.B. et al. Gastroenterology 130, 323–333 (2006).
Acknowledgements
We thank J. Arron, E. Brown, J. Monroe, J. Settleman and M. Townsend for discussions, and A. Bruce for assistance in illustration.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
A.C.C. and T.W.B. are employees of Genentech.
Rights and permissions
About this article
Cite this article
Chan, A., Behrens, T. Personalizing medicine for autoimmune and inflammatory diseases. Nat Immunol 14, 106–109 (2013). https://doi.org/10.1038/ni.2473
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.2473
This article is cited by
-
Neural regulation of immunity: molecular mechanisms and clinical translation
Nature Neuroscience (2017)
-
The IBD interactome: an integrated view of aetiology, pathogenesis and therapy
Nature Reviews Gastroenterology & Hepatology (2017)
-
Reducing the risk of failure: biomarker-guided trial design
Nature Reviews Drug Discovery (2016)
-
The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance: development of other autoantibodies and progression to type 1 diabetes
Diabetologia (2016)
-
Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics
Arthritis Research & Therapy (2014)
