The sensing of viral infection by the innate immune system is dominated by the recognition of nucleic acids. New data now demonstrate that the fusion of viral and target-cell membranes leads to the activation of an immune response dependent on the adaptor STING.
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Olagnier, D., Hiscott, J. Breaking the barrier: membrane fusion triggers innate antiviral immunity. Nat Immunol 13, 713–715 (2012). https://doi.org/10.1038/ni.2373
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DOI: https://doi.org/10.1038/ni.2373
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