Type 1 diabetes is usually diagnosed after most insulin-producing islets of Langerhans have already been destroyed. However, magnetic resonance imaging can be used to predict the onset of type 1 diabetes, and a benign prognosis correlates with the presence of anti-inflammatory tissue-resident macrophages.
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References
Fu, W., Wojtkiewicz, G., Benoist, C. & Mathis, D. Nat. Immunol. 13, 361–368 (2012).
Winter, W.E. & Schatz, D.A. Clin. Chem. 57, 168–175 (2011).
Serreze, D.V. et al. Diabetes 60, 2914–2921 (2011).
Fierabracci, A. Diabetes Metab. Res. Rev. 27, 216–229 (2011).
DiLorenzo, T.P. Diabetes Metab. Res. Rev. 27, 778–783 (2011).
Enée, E. et al. J. Immunol. 180, 5430–5438 (2008).
Jansen, A. et al. Diabetes 43, 667–675 (1994).
Turvey, S.E. et al. J. Clin. Invest. 115, 2454–2461 (2005).
Gaglia, J.L. et al. J. Clin. Invest. 121, 442–445 (2011).
Vogt, L. et al. J. Clin. Invest. 116, 2817–2826 (2006).
Miyanishi, M. et al. Nature 450, 435–439 (2007).
Mathis, D., Vence, L. & Benoist, C. Nature 414, 792–798 (2001).
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Chervonsky, A. Solving the plot: early events are the key to diabetes intervention. Nat Immunol 13, 311–312 (2012). https://doi.org/10.1038/ni.2259
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DOI: https://doi.org/10.1038/ni.2259
