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Variation across the allele frequency spectrum

Nature Genetics volume 42, pages 648–650 (2010)Cite this article

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A new study finds that individuals with high plasma triglyceride levels carry approximately twice as many rare, coding genetic variants within four candidate genes identified through genome-wide association studies than individuals without these high levels. This study demonstrates the overlap of rare and common variant signals at loci associated with lipid levels and shows the value of efforts to extend susceptibility variant discovery to embrace the full allele-frequency spectrum.

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Figure 1: Genetic susceptibility variants across the allele frequency spectrum.

References

  1. Manolio, T.A. et al. Nature 461, 747–753 (2009).

    Article  CAS  Google Scholar 

  2. Johansen, C.T. et al. Nat. Genet. 42, 684–687 (2010).

    Article  CAS  Google Scholar 

  3. Kathiresan, S. et al. Nat. Genet. 41, 56–65 (2009).

    Article  CAS  Google Scholar 

  4. Aulchenko, Y.S. et al. Nat. Genet. 41, 47–55 (2009).

    Article  CAS  Google Scholar 

  5. Romeo, S. et al. J. Clin. Invest. 119, 70–79 (2009).

    CAS  Google Scholar 

  6. Cohen, J.C., Boerwinkle, E., Mosley, T.H. Jr. & Hobbs, H.H. N. Engl. J. Med. 354, 1264–1272 (2006).

    Article  CAS  Google Scholar 

  7. Cirulli, E.T. & Goldstein, D.B. Nat. Rev. Genet. 11, 415–425 (2010).

    Article  CAS  Google Scholar 

  8. Ng, S.B. et al. Nat. Genet. 42, 30–35 (2010).

    Article  CAS  Google Scholar 

  9. Beer, N.L. et al. Hum. Mol. Genet. 18, 4081–4088 (2009).

    Article  CAS  Google Scholar 

  10. Saxena, R. et al. Science 316, 1331–1336 (2007).

    Article  CAS  Google Scholar 

  11. Orho-Melander, M. et al. Diabetes 57, 3112–3121 (2008).

    Article  CAS  Google Scholar 

  12. Dupuis, J. et al. Nat. Genet. 42, 105–116 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Anna L. Gloyn and Mark I. McCarthy are at the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.,

    Anna L Gloyn & Mark I McCarthy

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  1. Anna L Gloyn
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  2. Mark I McCarthy
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Correspondence to Mark I McCarthy.

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The authors declare no competing financial interests.

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Gloyn, A., McCarthy, M. Variation across the allele frequency spectrum. Nat Genet 42, 648–650 (2010). https://doi.org/10.1038/ng0810-648

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