A CRISPR screen conducted in a CD4+ T cell leukemia line has identified host factors required for HIV infection but dispensable for cellular survival. The results highlight sulfation on the HIV co-receptor CCR5 and cellular aggregation as potential targets for therapeutic intervention.
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Tsui, C., Gupta, A. & Bassik, M. Finding host targets for HIV therapy. Nat Genet 49, 175–176 (2017). https://doi.org/10.1038/ng.3777
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DOI: https://doi.org/10.1038/ng.3777