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Grand Challenge Commentary: Chemical transdifferentiation and regenerative medicine

Nature Chemical Biology volume 6, pages 877–879 (2010)Cite this article

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The ability to alter cell identity with small molecules represents a powerful approach to restore biological function lost because of cellular deficiency. Developing this capability through advances in chemical biology could have an enormous impact on human health.

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Figure 1: Examples illustrating the goal of altering cell fate using small molecules.
Figure 2: Transdifferentiation may help restore beta-cell mass lost in type 1 diabetes.

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Authors and Affiliations

  1. Bridget K. Wagner is in the Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.,

    Bridget K Wagner

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  1. Bridget K Wagner
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Correspondence to Bridget K Wagner.

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The author declares no competing financial interests.

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Wagner, B. Grand Challenge Commentary: Chemical transdifferentiation and regenerative medicine. Nat Chem Biol 6, 877–879 (2010). https://doi.org/10.1038/nchembio.472

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