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Kinase inhibitors

Narrowing down the real targets

Nature Chemical Biology volume 6, pages 249–250 (2010)Cite this article

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Many kinase inhibitors for cancer therapy are rather nonselective, and their cellular mechanisms of action are incompletely understood. A nested chemical proteomics and chemical genetics strategy reveals which cellular targets of the clinical kinase inhibitor dasatinib functionally relate to its anti-oncogenic activity.

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Figure 1: Nested chemical proteomics and genetics strategy for kinase inhibitor analysis.

References

  1. Karaman, M.W. et al. Nat. Biotechnol. 26, 127–132 (2008).

    Article  CAS  Google Scholar 

  2. Rix, U. & Superti-Furga, G. Nat. Chem. Biol. 5, 616–624 (2009).

    Article  CAS  Google Scholar 

  3. Li, J. et al. Nat. Chem. Biol. 6, 291–299 (2010).

    Article  CAS  Google Scholar 

  4. Huang, F. et al. Cancer Res. 67, 2226–2238 (2007).

    Article  CAS  Google Scholar 

  5. Sos, M.L. et al. J. Clin. Invest. 119, 1727–1740 (2009).

    Article  CAS  Google Scholar 

  6. Blencke, S. et al. Chem. Biol. 11, 691–701 (2004).

    Article  CAS  Google Scholar 

  7. Hantschel, O. et al. Proc. Natl. Acad. Sci. USA 104, 13283–13288 (2007).

    Article  CAS  Google Scholar 

  8. Haura, E.B. et al. J. Clin. Oncol. published online, doi:10.1200/JCO.2009.25.4029 (8 February 2010).

  9. Downward, J. Nature 462, 44–45 (2009).

    Article  CAS  Google Scholar 

  10. Pan, C., Olsen, J.V., Daub, H. & Mann, M. Mol. Cell. Proteomics 8, 2796–2808 (2009).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Molecular Biology, Henrik Daub is in the Project Group Cell Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.,

    Henrik Daub

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  1. Henrik Daub
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Correspondence to Henrik Daub.

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H.D. is a shareholder of and has a consultancy agreement with Kinaxo Biotechnologies GmbH.

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Daub, H. Narrowing down the real targets. Nat Chem Biol 6, 249–250 (2010). https://doi.org/10.1038/nchembio.336

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  • DOI: https://doi.org/10.1038/nchembio.336

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