Chemical genetics

Definition

Chemical genetics is the use of small molecule compounds to perturb a biological system to explore the outcome. Chemical genetics is also used to describe the technique of screening for small molecule modulators. As in classical genetics, the perturbation of a system using small molecules reveals information about the targeted system.

Latest Research and Reviews

  • Research |

    Inhibitors of CDK8 enhance IL-10 production during innate immune activation in human and mouse primary macrophages and dendritic cells via diminished phosphorylation of the c-Jun subunit of the AP-1 transcription regulatory complex.

    • Liv Johannessen
    • , Thomas B Sundberg
    • , Daniel J O'Connell
    • , Raivo Kolde
    • , James Berstler
    • , Katelyn J Billings
    • , Bernard Khor
    • , Brinton Seashore-Ludlow
    • , Anne Fassl
    • , Caitlin N Russell
    • , Isabel J Latorre
    • , Baishan Jiang
    • , Daniel B Graham
    • , Jose R Perez
    • , Piotr Sicinski
    • , Andrew J Phillips
    • , Stuart L Schreiber
    • , Nathanael S Gray
    • , Alykhan F Shamji
    •  & Ramnik J Xavier
    Nature Chemical Biology 13, 1102–1108
  • Research |

    Delayed resolution of G-quadruplexes during replication can induce localized loss of epigenetic information and changes in gene expression. Now, this effect has been used to discover biologically potent G-quadruplex ligands and to demonstrate that G-quadruplex stabilization can induce epigenetic changes that are heritable across cell divisions even after the ligand is removed.

    • Guillaume Guilbaud
    • , Pierre Murat
    • , Bénédicte Recolin
    • , Beth C. Campbell
    • , Ahmed Maiter
    • , Julian E. Sale
    •  & Shankar Balasubramanian
  • Research |

    Profiling of over 13,000 compounds against yeast gene deletion mutants, defining the differential responses on cells, reveals chemical-genetic interactions that can be used to predict compound function and their target pathways.

    • Jeff S Piotrowski
    • , Sheena C Li
    • , Raamesh Deshpande
    • , Scott W Simpkins
    • , Justin Nelson
    • , Yoko Yashiroda
    • , Jacqueline M Barber
    • , Hamid Safizadeh
    • , Erin Wilson
    • , Hiroki Okada
    • , Abraham A Gebre
    • , Karen Kubo
    • , Nikko P Torres
    • , Marissa A LeBlanc
    • , Kerry Andrusiak
    • , Reika Okamoto
    • , Mami Yoshimura
    • , Eva DeRango-Adem
    • , Jolanda van Leeuwen
    • , Katsuhiko Shirahige
    • , Anastasia Baryshnikova
    • , Grant W Brown
    • , Hiroyuki Hirano
    • , Michael Costanzo
    • , Brenda Andrews
    • , Yoshikazu Ohya
    • , Hiroyuki Osada
    • , Minoru Yoshida
    • , Chad L Myers
    •  & Charles Boone
  • Research | | open

    A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex.

    • Teng Teng
    • , Jennifer HC Tsai
    • , Xiaoling Puyang
    • , Michael Seiler
    • , Shouyong Peng
    • , Sudeep Prajapati
    • , Daniel Aird
    • , Silvia Buonamici
    • , Benjamin Caleb
    • , Betty Chan
    • , Laura Corson
    • , Jacob Feala
    • , Peter Fekkes
    • , Baudouin Gerard
    • , Craig Karr
    • , Manav Korpal
    • , Xiang Liu
    • , Jason T. Lowe
    • , Yoshiharu Mizui
    • , James Palacino
    • , Eunice Park
    • , Peter G. Smith
    • , Vanitha Subramanian
    • , Zhenhua Jeremy Wu
    • , Jian Zou
    • , Lihua Yu
    • , Agustin Chicas
    • , Markus Warmuth
    • , Nicholas Larsen
    •  & Ping Zhu

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