Technologies for engineering immune cells to recognize features on cancer cells are transforming oncology. Synthetic biologists now expand this approach by conferring therapeutic functions to nonimmune cells and by programming cells to sense and respond to a new class of physiological cues.
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References
Hartmann, J., Schüßler-Lenz, M., Bondanza, A. & Buchholz, C.J. EMBO Mol. Med. 9, 1183–1197 (2017).
Dolgin, E. Nat. Biotechnol. 35, 891–892 (2017).
American Association for Cancer Research. Cancer Discov. 8, 5–6 (2018).
Bach, P.B., Giralt, S.A. & Saltz, L.B. JAMA 318, 1861–1862 (2017).
Lim, W.A. & June, C.H. Cell 168, 724–740 (2017).
Kojima, R., Scheller, L. & Fussenegger, M. Nat. Chem. Biol. 14, 42–49 (2018).
Chang, Z.L. et al. Nat. Chem. Biol. 14, 317–324 (2018).
Haellman, V. & Fussenegger, M. Curr. Opin. Biomed. Eng. 4, 50–56 (2017).
Muldoon, J.J., Donahue, P.S., Dolberg, T.B. & Leonard, J.N. Curr. Opin. Biomed. Eng. 4, 127–133 (2017).
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Dolberg, T., Donahue, P. & Leonard, J. Reframing cell therapy for cancer. Nat Chem Biol 14, 204–205 (2018). https://doi.org/10.1038/nchembio.2573
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DOI: https://doi.org/10.1038/nchembio.2573