A highly selective JAK3 inhibitor with subnanomolar potency has been used to identify two waves of STAT5 phosphorylation in response to IL-2. This reveals a biphasic role for JAK3 catalytic activity in IL-2-mediated signaling that has therapeutic implications.
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W.J.L. and S.M. are inventors related to a patent application on H9-RETR.
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Leonard, W., Mitra, S. & Lin, JX. JAK3 inhibition—is it sufficient?. Nat Chem Biol 12, 308–310 (2016). https://doi.org/10.1038/nchembio.2066
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DOI: https://doi.org/10.1038/nchembio.2066
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