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DNA metabolism

Bases of DNA repair and regulation

An Erratum to this article was published on 13 November 2014

Recent studies have identified the existence of modified cytosine bases in DNA that result from ten eleven translocation (Tet)-mediated oxidation of 5-methylcytosine. The demonstration that Tet oxidizes thymine to 5-hydroxymethyluracil has implications for our current view of DNA metabolism.

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Figure 1: 5hmU in genomic DNA is the result of Tet-induced oxidation or ROS exposure.

References

  1. Tahiliani, M. et al. Science 324, 930–935 (2009).

    Article  CAS  Google Scholar 

  2. Pfaffender, T. et al. Nat. Chem. Biol. 10, 574–581 (2014).

    Article  Google Scholar 

  3. He, Y.F. et al. Science 333, 1303–1307 (2011).

    Article  CAS  Google Scholar 

  4. Ito, S. et al. Science 333, 1300–1303 (2011).

    Article  CAS  Google Scholar 

  5. Guo, J.U., Su, Y., Zhong, C., Ming, G.L. & Song, H. Cell 145, 423–434 (2011).

    Article  CAS  Google Scholar 

  6. Cortellino, S. et al. Cell 146, 67–79 (2011).

    Article  CAS  Google Scholar 

  7. Nabel, C.S. et al. Nat. Chem. Biol. 8, 751–758 (2012).

    Article  CAS  Google Scholar 

  8. Boorstein, R.J. et al. J. Biol. Chem. 2076, 41991–41997 (2001).

    Article  Google Scholar 

  9. Krokan, H.E. et al. DNA Repair (Amst.) (in the press).

  10. Spruijt, C.G. et al. Cell 152, 1146–1159 (2013).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Arne Klungland.

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Robertson, A., Dahl, J. & Klungland, A. Bases of DNA repair and regulation. Nat Chem Biol 10, 487–488 (2014). https://doi.org/10.1038/nchembio.1553

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