Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments.
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Zheng, W., Pollard, J. What DKKtates where to metastasize. Nat Cell Biol 19, 1146–1148 (2017). https://doi.org/10.1038/ncb3621
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DOI: https://doi.org/10.1038/ncb3621