The heart is a complex organ, consisting of multiple cell types that coordinately regulate blood flow. Reciprocal Notch pathway signalling in endocardial and myocardial cells is now shown to promote maturation of the ventricular chambers. These insights reveal mechanisms that, when disrupted, can lead to cardiomyopathies.
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Gifford, C., Srivastava, D. Heart disease modelling adds a Notch to its belt. Nat Cell Biol 18, 3–5 (2016). https://doi.org/10.1038/ncb3294
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DOI: https://doi.org/10.1038/ncb3294