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TSC on the peroxisome controls mTORC1

Nature Cell Biology volume 15, pages 1135–1136 (2013)Cite this article

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mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species. Thus, mTOR may avoid confounding different inputs by sensing them at different cellular locations.

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Figure 1: Model of a hypothetical mTORC1 signalling node on the peroxisome.

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Authors and Affiliations

  1. Don Benjamin and Michael N. Hall are at Biozentrum, University of Basel, CH4056 Basel, Switzerland,

    Don Benjamin & Michael N. Hall

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  1. Don Benjamin
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  2. Michael N. Hall
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Correspondence to Michael N. Hall.

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Benjamin, D., Hall, M. TSC on the peroxisome controls mTORC1. Nat Cell Biol 15, 1135–1136 (2013). https://doi.org/10.1038/ncb2849

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