Cellular senescence is a potent tumour suppressor mechanism that is often accompanied by activation of DNA damage response (DDR) signalling and marked heterochromatinization. Senescence-associated heterochromatin is now shown to limit DDR, thus reducing apoptosis and promoting survival of senescent cells.
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Ivanov, A., Adams, P. A damage limitation exercise. Nat Cell Biol 13, 193–195 (2011). https://doi.org/10.1038/ncb0311-193
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DOI: https://doi.org/10.1038/ncb0311-193
