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Myc-modulated miR-9 makes more metastases

Nature Cell Biology volume 12, pages 209–211 (2010)Cite this article

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The microRNA miR-9 is induced by Myc in breast cancer cells where it targets the major epithelial adherens junction protein, E-cadherin. This primes the cancer cells for epithelial–mesenchymal transition (EMT) and also stimulates angiogenesis in tumours.

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Figure 1: miR-9 downregulates E-cadherin to disrupt adherens junctions and allow β-catenin-mediated transcription.

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  1. Yeesim Khew-Goodall and Gregory J Goodall are in the Centre for Cancer Biology, SA Pathology, Adelaide, Australia.,

    Yeesim Khew-Goodall & Gregory J. Goodall

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  1. Yeesim Khew-Goodall
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  2. Gregory J. Goodall
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Correspondence to Gregory J. Goodall.

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The authors declare no competing financial interests.

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Khew-Goodall, Y., Goodall, G. Myc-modulated miR-9 makes more metastases. Nat Cell Biol 12, 209–211 (2010). https://doi.org/10.1038/ncb0310-209

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