An optical spectroscopy method can measure the affinities of ligands to membrane receptors that are embedded in their native membranes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Baksh, M.M. et al. Nat Biotechnol. 29, 357–360 (2011).
Tilakaratne, N. & Sexton, P.M. Clin. Exp. Pharmacol. Physiol. 32, 979–987 (2005).
Smith, N.J. & Milligan, G. Pharmacol. Rev. 62, 701–725 (2010).
Keiser, M.J. et al. Biochemistry 49, 10267–10276 (2010).
Schröder, R. et al. Nat. Biotechnol. 28, 943–949 (2010).
Whitehurst, C.E. & Annis, D.A. Comb. Chem. High Throughput Screen. 11, 427–438 (2008).
Dodgson, K. et al. J. Recept. Signal Transduct. Res. 29, 163–172 (2009).
Kussrow, A. et al. Chembiochem. published online, doi:10.1002/cbic.201000671 (29 December 2010).
Conn, P.J. et al. Nat. Rev. Drug Discov. 8, 41–54 (2009).
Eglen, R. & Reisine, T. Assay Drug Dev. Technol. published online, doi:10.1089/adt.2010.0305 (27 December 2010).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author is employed by Merck Sharp and Dohme Corp.
Rights and permissions
About this article
Cite this article
Lunn, C. A new look at membrane protein binding. Nat Biotechnol 29, 328–329 (2011). https://doi.org/10.1038/nbt.1820
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt.1820