The T cells of the immune system can destroy tumours, but their activation can be inefficient. Vaccines that exploit tumour mutations elicit robust T-cell responses to tumours, with potential clinical benefits. See Letters p.217 & p.222
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References
Pitt, J. M. et al. Ann. Oncol. 27, 1482–1492 (2016).
Naidoo, J. et al. Ann. Oncol. 26, 2375–2391 (2015).
Castle, J. C. et al. Cancer Res. 72, 1081–1091 (2012).
Gubin, M. M. et al. Nature 515, 577–581 (2014).
Carreno, B. M. et al. Science 348, 803–808 (2015).
Ott, P. et al. Nature 547, 217–221 (2017).
Sahin, U. et al. Nature 547, 222–226 (2017).
van der Burg, S. H., Arens, R., Ossendorp, F., van Hall, T. & Melief, C. J. Nature Rev. Cancer 16, 219–233 (2016).
Szczepaniak Sloane, R. A. et al. Cancer 123, 2130–2142 (2017).
Kreiter, S. et al. Cancer Res. 70, 9031–9040 (2010).
Hirschhorn-Cymerman, D. et al. J. Exp. Med. 209, 2113–2126 (2012).
Haabeth, O. A. et al. Leukemia 30, 1216–1220 (2016).
Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R. & Melief, C. J. Nature 393, 480–483 (1998).
Janssen, E. M. et al. Nature 421, 852–856 (2003).
Alexandrov, L. B. et al. Nature 500, 415–421 (2013).
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Melief, C. Precision T-cell therapy targets tumours. Nature 547, 165–167 (2017). https://doi.org/10.1038/nature23093
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DOI: https://doi.org/10.1038/nature23093