Sex determination in the silkworm Bombyx mori has been found to depend on the presence or absence of a small RNA. This is thought to be the first example of a molecule other than a protein mediating this process. See Letter p.633
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Marec, F. Female silkworms have the sex factor. Nature 509, 570–571 (2014). https://doi.org/10.1038/nature13336
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DOI: https://doi.org/10.1038/nature13336