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Genomic resources for the study of neuropsychiatric disorders

Molecular Psychiatry volume 22, pages 1659–1663 (2017)Cite this article

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Abstract

The National Institute of Mental Health (NIMH) has made sustained investments in the development of genomic resources over the last two decades. These investments have led to the development of the largest biorepository for psychiatric genetics as a centralized national resource. In the realm of genomic resources, NIMH has been supporting large team science (TS) consortia focused on gene discovery, fine mapping of loci, and functional genomics using state-of-the-art technologies. The scientific output from these efforts has not only begun to transform our understanding of the genetic architecture of neuropsychiatric disorders, but it has also led to a broader cultural change among the investigator community towards deeper collaborations and broad pre-publication sharing of data and resources. The NIMH supported efforts have led to a vast increase in the amount of genetic and genomic resources available to the mental health research community. Here we provide an account of the existing resources and estimates of the scale and scope of what will be available in the near future. All biosamples and data described are intended for broad sharing with researchers worldwide, as allowed by the subject consent and applicable laws.

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Acknowledgements

We thank Dr John Rice and his group at Washington University in St Louis; Drs Jay Tischfield and Linda Brzustowicz, and their group at Rutgers University; Dr Yigal Arens and his group at the Information Sciences Institute at University of Southern California, and the dbGaP and NDA staff for their help with data and sample accounting. We also acknowledge the efforts of several members of our TS and functional genomics consortia in providing up to date details on their data generation efforts, including Drs Pamela Sklar and Nenad Sestan.

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The views and opinions expressed in this article are those of the authors and should not be construed to represent the views of any of the sponsoring organization, agencies or the United States government.

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  1. Office of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA

    G Senthil, T Dutka, L Bingaman & T Lehner

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  1. G Senthil
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  2. T Dutka
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Correspondence to T Lehner.

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Supplementary Information accompanies the paper on the Molecular Psychiatry website

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Senthil, G., Dutka, T., Bingaman, L. et al. Genomic resources for the study of neuropsychiatric disorders. Mol Psychiatry 22, 1659–1663 (2017). https://doi.org/10.1038/mp.2017.29

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