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Exploring functional polymorphisms in the dopamine receptor D2 gene using prolactin concentration in healthy subjects

Molecular Psychiatry volume 16, pages 356–358 (2011)Cite this article

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Prolactin (PRL) secretion is regulated by hypothalamic dopaminergic systems such as the tuberoinfundibular, tuberohypophyseal and periventricular hypophyseal dopaminergic neurons. Dopamine from these neurons diffuses into capillaries of the pituitary portal blood vessels and is transported to the anterior pituitary, where it acts on dopamine receptor D2 (DRD2) on lactotrophs to inhibit PRL secretion.1

DRD2 has been extensively investigated in relation to its pathological association with neuropsychiatric disorders such as drug addiction,2 schizophrenia3 and Parkinson's disease.4 The DRD2 single-nucleotide polymorphisms (SNPs) –141C ins/del, Ser311Cys and Taq1 A have been reported to be associated with these neuropsychiatric disorders and antipsychotic response; however, these associations have not been consistently replicated. Furthermore, it was recently reported that Taq1 A is located not within DRD2, but within the ankyrin repeat and kinase domain containing 1 gene, less than 10 kb downstream of DRD2. Therefore, detecting the significant functional DRD2 polymorphisms may be important in understanding the pathogenesis of these neuropsychiatric disorders.

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Authors and Affiliations

  1. Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

    N Fukui, Y Suzuki, T Sugai, J Watanabe, S Ono, N Tsuneyama & T Someya

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  1. N Fukui
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  2. Y Suzuki
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  3. T Sugai
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  4. J Watanabe
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  5. S Ono
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  6. N Tsuneyama
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  7. T Someya
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Correspondence to T Someya.

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Fukui, N., Suzuki, Y., Sugai, T. et al. Exploring functional polymorphisms in the dopamine receptor D2 gene using prolactin concentration in healthy subjects. Mol Psychiatry 16, 356–358 (2011). https://doi.org/10.1038/mp.2010.37

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