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Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications

Leukemia volume 25, pages 1095–1102 (2011)Cite this article

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Abstract

The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; however, advances in the field of embryonic SCs and induced pluripotent SCs may change this situation. Interest into in vitro generation of HSCs, including signals for HSC expansion and differentiation from these more primitive SCs, as well as advances in other organ-specific SCs, in particular the intestine, provide promising new applications for SC therapies. Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of emerging SC technologies.

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Acknowledgements

We thank Amber Gunthardt for excellent organizational skills and Veruli Illustrations for assistance with visual art.

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Authors and Affiliations

  1. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

    F J T Staal, M Van Pel, J J Zwaginga & W E Fibbe

  2. Department of Experimental Hematology, Medical School Hannover, Hannover, Germany

    C Baum

  3. Department of Medicine, Massachusetts General Hospital, Boston, MA, USA

    C Cowan

  4. Department of Cell Biology, Erasmus MC Stem Cell Institute, Rotterdam, The Netherlands

    E Dzierzak & C Robin

  5. Department of Biotherapy, Hôpital Necker, Paris, France

    S Hacein-Bey-Abina

  6. Department of Molecular Medicine, Lund University, Lund, Sweden

    S Karlsson

  7. Department of Immunology, Weizmann Institute, Rehovot, Israel

    T Lapidot

  8. Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY, USA

    I Lemischka, S Mendez-Ferrer & K Moore

  9. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

    H Mikkers

  10. Department of Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

    E Moreno

  11. Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands

    C L Mummery

  12. Department of Cell Differentiation, Keio University School of Medicine, Tokyo, Japan

    T Suda

  13. Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands

    G Vanden Brink

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  1. F J T Staal
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Staal, F., Baum, C., Cowan, C. et al. Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications. Leukemia 25, 1095–1102 (2011). https://doi.org/10.1038/leu.2011.52

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