Self-renewal is the process of giving rise to indefinitely more cells of the same cell type. All stem cells have the capacity to self-renew by dividing.

Latest Research and Reviews

News and Comment

  • News and Views |

    Altered stem cell homeostasis underlies functional tissue decline during muscle aging and disease progression. Janus kinase–signal transducer and activator of transcription (JAK-STAT) signal transduction is a crucial regulator of muscle regeneration, and targeting this pathway in mice relieves aspects of debilitating muscle wasting.

    • Jason D Doles
    •  & Bradley B Olwin
    Nature Medicine 20, 1094–1095
  • News and Views |

    The role of RNA splicing in the regulation of stem cell properties has remained largely unexplored. The splicing-associated protein SON is now shown to be necessary for embryonic stem cell maintenance, by influencing the splicing of pluripotency regulators.

    • Ilana Livyatan
    •  & Eran Meshorer
    Nature Cell Biology 15, 1139–1140
  • News and Views |

    Decreased muscle stem cell function in aging has long been shown to depend on altered environmental cues, whereas the contribution of intrinsic mechanisms remained less clear. Two new studies now reveal that cell-autonomous changes in the p38 mitogen-activated protein kinase pathway are major phenotype determinants of aged muscles stem cells (pages 255–271).

    • C Florian Bentzinger
    •  & Michael A Rudnicki
    Nature Medicine 20, 234–235