Abstract
We describe the use of tin-mesoporphyrin (SnMP) in the treatment of an infant with Rh hemolytic disease. The infant's hyperbilirubinemia responded to phototherapy but every time the phototherapy was discontinued, the serum bilirubin rebounded and repeat phototherapy was necessary. A single intramuscular dose of SnMP on day 18 eliminated the need for further phototherapy and allowed us to discharge this infant.
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References
Kappas A . A method for interdicting the development of severe jaundice in newborns by inhibiting the production of bilirubin. Pediatrics 2004; 113: 119–123.
Strauss KA, Robinson DL, Vreman HJ, Puffenberger EG, Hart G, Morton DH . Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. Eur J Pediatr 2006; 165: 306–319.
Valaes T, Drummond GS, Kappas A . Control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns using an inhibitor of bilirubin production, Sn-mesoporphyrin. Pediatrics 1998; 101 (5): e1.
Valaes T, Petmezaki S, Henschke C, Drummond GS, Kappas A . Control of jaundice in preterm newborns by an inhibitor of bilirubin production: Studies with tin-mesoporphyrin. Pediatrics 1994; 93: 1–11.
Martinez JC, Garcia HO, Otheguy L, Drummond GS, Kappas A . Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin. Pediatrics 1999; 103: 1–5.
Bhutani VK, Meloy LD, Poland RL, Hegyi T, Maisels MJ, Fanaroff AA et al. Randomized placebo-controlled clinical trial of stannsoporfin (Sn-MP) to prevent severe hyperbilirubinemia in term and near-term infants. Pediatr Res 2004; 55: 448A.
Kappas A, Drummond GS, Valaes T . A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns. Pediatrics 2001; 108 (1): 25–30.
Kappas A, Drummond GS, Manola T, Petmezaki S, Valaes T . Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs’-positive ABO incompatibility. Pediatrics 1988; 81: 485–497.
Kappas A, Drummond G, Henschke C, Valaes T . Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns. Pediatrics 1995; 95: 468–474.
Kappas A, Drummond GS, Munson DP, Marshall JR . Sn-mesoporphyrin interdiction of severe hyperbilirubinemia in Jehovah's Witness newborns as an alternative to exchange transfusion. Pediatrics 2001; 108: 1374–1377.
Tulloch S . Personal Communication. Infacare Pharmaceutical 2011.
Kaplan M, Kaplan E, Hammerman C, Algur N, Bromiker R, Schimmel MS et al. Post-phototherapy neonatal bilirubin rebound: a potential cause of significant hyperbilirubinaemia. Arch Dis Child 2006; 91: 31–34.
Maisels MJ, Kring E . Rebound in serum bilirubin level following intensive phototherapy. Arch Pediatr Adolesc Med 2002; 156: 669–672.
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We thank Jon F Watchko, MD, for his review of this manuscript.
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Dr Maisels has acted as a consultant for InfaCare Pharmaceutical Corporation.
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Maisels, M., Yang, H. Tin-mesoporphyrin in the treatment of refractory hyperbilirubinemia due to Rh incompatibility. J Perinatol 32, 899–900 (2012). https://doi.org/10.1038/jp.2012.45
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DOI: https://doi.org/10.1038/jp.2012.45