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Histological chorioamnionitis and bronchopulmonary dysplasia: a retrospective cohort study

Journal of Perinatology volume 33, pages 441–445 (2013)Cite this article

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Abstract

Objective:

To examine the association between histological chorioamnionitis (HC) with or without fetal inflammatory response (FIR) and bronchopulmonary dysplasia (BPD) in preterm infants.

Study Design:

We conducted a retrospective cohort study of infants born at <29 weeks gestation admitted to the neonatal intensive care unit from 2000 to 2006, who had placental histology. We compared the incidence of BPD among three groups: No HC group, HC without FIR group and HC with FIR group. The multivariable model based on generalized estimating equation was fitted to estimate the adjusted risk ratios (aRR) and 95% confidence intervals (CIs) for BPD and combined outcome of BPD or death.

Result:

Of 529 infants, 84 (16%) had HC without FIR, 186 (35%) had HC with FIR and 259 (49%) had no HC. Compared with the no HC group, HC with and without FIR group infants were of lower gestational age and singleton births. Multivariable modeling based on generalized estimating equation revealed that HC with FIR is associated with decreased risk of both BPD (aRR 0.88, 95% CI 0.81 to 0.95) and the combined outcome of BPD or death (aRR 0.91, 95% CI 0.86 to 0.97). HC without FIR showed a trend toward reduction in BPD (aRR 0.93, 95% CI 0.86 to 1.00).

Conclusions:

HC with FIR is associated with decreased risk of both BPD and the combined outcome of BPD or death in preterm infants.

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Acknowledgements

This study was financially supported by the Alberta Children’s Hospital Foundation.

Author information

Authors and Affiliations

  1. Department of Pediatrics and Alberta Children’s Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, AT, Canada

    N Plakkal, A Singh Soraisham & R Sauve

  2. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AT, Canada

    C Trevenen

  3. Department of Community Health Sciences, University of Calgary, Calgary, AT, Canada

    E A Freiheit & R Sauve

Authors
  1. N Plakkal
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  2. A Singh Soraisham
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  3. C Trevenen
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  4. E A Freiheit
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  5. R Sauve
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Correspondence to A Singh Soraisham.

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Plakkal, N., Soraisham, A., Trevenen, C. et al. Histological chorioamnionitis and bronchopulmonary dysplasia: a retrospective cohort study. J Perinatol 33, 441–445 (2013). https://doi.org/10.1038/jp.2012.154

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