Abstract
The aim of this study was to evaluate the usefulness and specificity of urinary 1-hydroxypyrene (1-OHPu) as a biomarker of the exposure from urban pollution to polycyclic aromatic hydrocarbons (PAHs) among outdoor workers in a meta-analysis. Our meta-analysis was performed according to standard methods, and the results show that the concentrations of 1-OHPu tend to be higher in exposed workers than in unexposed workers (if we exclude two highly heterogeneous articles), in exposed non-smokers than in unexposed non-smokers and in exposed than in unexposed workers who were carriers of the CYP1A1 genotype and in those with the glutathione-S-transferase M1 (−)genotype. These genotypes enhance the effect of exposure, particularly in non-smokers. Smoking reduces the differences between exposed and unexposed subjects. In conclusion, our results suggest that the use of the 1-OHPu biomarker appears to be reliable for studying occupational exposure to PAHs from urban pollution, as long as environmental and behavioural factors are considered.
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Abbreviations
- CYP:
-
cytochrome P450
- GST:
-
glutathione S-transferase
- 1-OHPu:
-
urinary 1-hydroxypyrene
- PAHs:
-
polycyclic aromatic hydrocarbons
- PYRH:
-
hydrocarbon pyrene
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Ciarrocca, M., Rosati, M., Tomei, F. et al. Is urinary 1-hydroxypyrene a valid biomarker for exposure to air pollution in outdoor workers? A meta-analysis. J Expo Sci Environ Epidemiol 24, 17–26 (2014). https://doi.org/10.1038/jes.2012.111
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DOI: https://doi.org/10.1038/jes.2012.111
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