Abstract
Objectives:
The life-course development of body mass index (BMI) may be driven by interactions between genes and obesity-inducing social environments. We examined whether lower parental or own education accentuates the genetic risk for higher BMI over the life course, and whether diet and physical activity account for the educational differences in genetic associations with BMI.
Subjects/Methods:
The study comprised 2441 participants (1319 women, 3–18 years at baseline) from the prospective, population-based Cardiovascular Risk in Young Finns Study. BMI (kg/m2) trajectories were calculated from 18 to 49 years, using data from six time points spanning 31 years. A polygenic risk score for BMI was calculated as a weighted sum of risk alleles in 97 single-nucleotide polymorphisms. Education was assessed via self-reports, measured prospectively from participants in adulthood and from parents when participants were children. Diet and physical activity were self-reported in adulthood.
Results:
Mean BMI increased from 22.6 to 26.6 kg/m2 during the follow-up. In growth curve analyses, the genetic risk score was associated with faster BMI increase over time (b=0.02, (95% CI, 0.01–0.02, P<0.001)). The association between the genetic risk score and BMI was more pronounced among those with lower educational level in adulthood (b=−0.12 (95% CI, −0.23–0.01); P=0.036)). No interaction effect was observed between the genetic risk score and parental education (b=0.05 (95% CI, −0.09–0.18; P=0.51)). Diet and physical activity explained little of the interaction effect between the genetic risk score and adulthood education.
Conclusions:
In this prospective study, the association of a risk score of 97 genetic variants with BMI was stronger among those with low compared with high education. This suggests lower education in adulthood accentuates the risk of higher BMI in people at genetic risk.
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Acknowledgements
This study was supported by the Academy of Finland grants 265869 (Dr Keltikangas-Järvinen); 265977 (Dr Elovainio); 258578 (Dr Hintsanen); 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Kuopio, Tampere and Turku University Hospital Medical Funds (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation of Cardiovascular Research; Finnish Cultural Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; and Signe and Ane Gyllenberg Foundation (Dr Lehtimäki). The expert technical assistance in the statistical analyses by Irina Lisinen is gratefully acknowledged. The funding sources had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication. This manuscript is an original contribution. Neither this manuscript or one with substantially similar content has been published or is being considered for publication elsewhere.
Author contributions
Ms Komulainen and Dr Pulkki-Råback had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis; study concept and design: Komulainen, Pulkki-Råback, Jokela, Keltikangas-Järvinen; acquisition, analysis and interpretation of data: all authors; drafting of the manuscript: Komulainen, Pulkki-Råback, Jokela; critical revision of the manuscript for important intellectual content: all authors; statistical analysis: Komulainen, Jokela; obtained funding: Keltikangas-Järvinen, Elovainio, Hintsanen, Lehtimäki; study supervision: Raitakari, Lehtimäki, Keltikangas-Järvinen. All authors have given final approval of the submitted manuscript. All authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The corresponding author (Pulkki-Råback) confirms to have the final responsibility for the decision to submit for publication.
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Komulainen, K., Pulkki-Raback, L., Jokela, M. et al. Education as a moderator of genetic risk for higher body mass index: prospective cohort study from childhood to adulthood. Int J Obes 42, 866–871 (2018). https://doi.org/10.1038/ijo.2017.174
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DOI: https://doi.org/10.1038/ijo.2017.174
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