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  • Original Article
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Clinical Studies and Practice

Circadian rhythmicity as a predictor of weight-loss effectiveness

International Journal of Obesity volume 38, pages 1083–1088 (2014)Cite this article

Subjects

Abstract

Objectives:

Some of the major challenges associated with successful dietary weight management include the identification of individuals not responsive to specific interventions. The aim was to investigate the potential relationship between weight loss and circadian rhythmicity, using wrist temperature and actimetry measurements, in women undergoing a weight-loss program, in order to assess whether circadian rhythmicity could be a marker of weight-loss effectiveness.

Methods:

Participants were 85 overweight and obese women (body mass index, BMI: 30.24±4.95 kg m−2) subjected to a weight-reduction program. Efficacy of the treatment was defined as total weight loss, percentage of initial weight and weekly weight loss rates. Circadian rhythmicity in wrist temperature motor activity and position were analyzed using different sensors.

Results:

Lower weight loss was related with a more flattened pattern measured as amplitude from cosinor (r=0.235, P=0.032), a higher fragmentation of rhythms determined by higher intradaily variability (IV) (r=−0.339, P=0.002), and an impaired wrist temperature circadian rhythm determined by the means of Circadian Function Index (r=0.228, P=0.038). Further analyses showed that low responders displayed lower amplitude (0.71±0.36 versus 1.24±0.62, P=0.036) and higher fragmentation of the circadian rhythm (0.24±0.11 versus 0.15±0.07, P=0.043) than high responders. Whereas we did not find significant differences in total activity rates between high responders and low responders, we found significant differences for the mean values of body position for high responders (39.12±3.79°) as compared with low responder women (35.31±2.53°, P=0.01).

Conclusions:

Circadian rhythms at the beginning of the treatment are good predictors of future weight loss. Further treatment should consider chronobiological aspects to diagnose obesity and effectiveness of treatments.

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Acknowledgements

We want to thank all the patients for their participation in this study, and also José Cánovas Lorente for his support and help in data collection and processing.

Author information

Authors and Affiliations

  1. Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain

    C Bandín, A Martinez-Nicolas, J A Madrid & M Garaulet

  2. Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Nutrition and Genomics Laboratory, Tufts University, Boston, MA, USA

    J M Ordovás

  3. Department of Epidemiology, Centro Nacional Investigaciones Cardiovasculares, Madrid, Spain

    J M Ordovás

  4. Madrid Institute for Advanced Studies in Food (IMDEA-FOOD), Madrid, Spain

    J M Ordovás

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  1. C Bandín
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Correspondence to M Garaulet.

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Bandín, C., Martinez-Nicolas, A., Ordovás, J. et al. Circadian rhythmicity as a predictor of weight-loss effectiveness. Int J Obes 38, 1083–1088 (2014). https://doi.org/10.1038/ijo.2013.211

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