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Caloric restriction, aerobic exercise training and soluble lectin-like oxidized LDL receptor-1 levels in overweight and obese post-menopausal women

International Journal of Obesity volume 35, pages 793–799 (2011)Cite this article

Subjects

Abstract

Background:

Elevated circulating levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) have been observed in obese persons and are reduced by weight loss. However, it is not known whether combining caloric restriction (CR) with exercise training is better in reducing sLOX-1 levels than CR alone.

Objective:

We examined whether the addition of aerobic exercise to a weight loss intervention differentially affects sLOX-1 levels in 61 abdominally obese post-menopausal women randomly assigned to a CR only (n=22), CR+moderate-intensity exercise (n=22) or CR+vigorous-intensity exercise (n=17) intervention for 20 weeks. The caloric deficit was ∼2800 kcal per week for all groups.

Results:

The intervention groups were similar at baseline with respect to body weight, body composition, lipids and blood pressure. However, plasma sLOX-1 levels were higher in the CR-only group (99.90±8.23 pg ml−1) compared with both the CR+moderate-intensity exercise (69.39±8.23 pg ml−1, P=0.01) and the CR+vigorous-intensity exercise (72.83±9.36 pg ml−1, P=0.03) groups. All three interventions significantly reduced body weight (∼14%), body fat and waist and hip circumferences to a similar degree. These changes were accompanied by a 23% reduction in sLOX-1 levels overall (−19.00±30.08 pg ml−1, P<0.0001), which did not differ among intervention groups (P=0.13). Changes in body weight, body fat and maximal oxygen consumption (VO2 max) were not correlated with changes in sLOX-1 levels. In multiple regression analyses in all women combined, baseline sLOX-1 levels (β=−0.70±0.06, P<0.0001), age (β=0.92±0.43, P=0.03) and baseline body mass index (BMI) (β=1.88±0.66, P=0.006) were independent predictors of the change in sLOX-1 with weight loss.

Conclusions:

Weight loss interventions of equal energy deficit have similar effects on sLOX-1 levels in overweight and obese post-menopausal women, with the addition of aerobic exercise having no added benefit when performed in conjunction with CR.

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Acknowledgements

We are grateful to the study coordinators, dietitians, exercise physiologists, nurses and other research staff of the Wake Forest University General Clinical Research Center and Geriatric Research Center for their assistance in the conduct of this study. We would also like to thank all the women who volunteered to participate in this study. This study was supported by NIH grants R01-AG/DK20583, the Wake Forest University Claude D Pepper Older Americans Independence Center (P30-AG21332) and the Wake Forest University General Clinical Research Center (M01-RR07122).

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Authors and Affiliations

  1. Department of Internal Medicine, J Paul Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    T E Brinkley, X Wang & B J Nicklas

  2. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    N Kume & H Mitsuoka

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  1. T E Brinkley
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  2. X Wang
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Correspondence to T E Brinkley.

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Brinkley, T., Wang, X., Kume, N. et al. Caloric restriction, aerobic exercise training and soluble lectin-like oxidized LDL receptor-1 levels in overweight and obese post-menopausal women. Int J Obes 35, 793–799 (2011). https://doi.org/10.1038/ijo.2010.199

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