Abstract
Cardiorespiratory fitness (CRF) has been reported to be inversely associated with visceral adipose tissue (VAT) accumulation, independent of body weight. However, the confounding effect of physical activity on the association between CRF and VAT remains inadequately addressed. On the basis of maximal oxygen uptake (VO2max), 143 sedentary, overweight women were dichotomized into high-fit (HF) and low-fit (LF) groups. Body composition and VAT were measured using dual-energy X-ray absorptiometry and computed tomography, respectively, and activity-related energy expenditure (AEE) was calculated using the doubly labeled water technique. No differences were observed between HF and LF for body mass index (HF 28.2±1.3; LF 28.3±1.31 kg m−2), total body weight (HF 77.5±6.8; LF 77.9±7.3 kg), total fat mass (HF 33.5±5.1; LF 33.9±4.4 kg) or AEE (HF 439.9±375.4; LF 517.9±298.7 kcal day−1). Significant differences in visceral adiposity (HF 68.5±30.4; LF 91.2±31.8 cm2; P<0.001) and insulin sensitivity (HF 5.1±1.8; LF 3.1±2.4 SI × 10−4 min−1 μIU−1 ml−1; P<0.01) were observed between the HF and LF groups, independent of age, race and AEE. This study affirms previous findings that CRF is an important determinant of the accumulation of VAT, and this relationship is independent of physical activity.
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Acknowledgements
This research was in part supported by National Institute of Health grants R01 DK 49779, T32-HL007457–25, General Clinical Research Center grant M01 RR-00032, Clinical Nutrition Research Unit grant P30-DK 56336, and KL2 RR084151 (to BAI).
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Study concept and design: DW Brock, B Gower, and GR Hunter; acquisition of data: DW Brock, B Gower, and GR Hunter; drafting of the paper: DW Brock, GR Hunter and BA Irving; critical revision of the paper for important intellectual content: DW Brock, BA Irving, B Gower, and GR Hunter; statistical expertise: GR Hunter and DW Brock; administrative, technical or material support: DW Brock and GR Hunter; and study supervision: GR Hunter and DW Brock.
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Brock, D., Irving, B., Gower, B. et al. Differences emerge in visceral adipose tissue accumulation after selection for innate cardiovascular fitness. Int J Obes 35, 309–312 (2011). https://doi.org/10.1038/ijo.2010.133
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DOI: https://doi.org/10.1038/ijo.2010.133
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