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  • RESEARCH HIGHLIGHT

Combination treatment for immune-mediated HIV remission

In rhesus macaques, treatment with an IL-15 superagonist and broad neutralizing antibodies led to durable suppression of viremia after discontinuation of antiretroviral therapy.
  1. Karen O’Leary

    1. Karen O’Leary is an Associate Research Analysis Editor with Nature Medicine.

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Antiretroviral therapy (ART) can effectively suppress human immunodeficiency virus (HIV) replication but cannot eliminate the latent viral reservoir from T cells — which leads to viral rebound if ART is discontinued.

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doi: https://doi.org/10.1038/d41591-024-00020-6

UPDATES & CORRECTIONS

Correction 02 April 2024: In the version of this Research Highlight originally published, the number of study animals and doses noted were incorrect. The sentence that originally read “Thirteen animals were treated with N-803 (six weekly subcutaneous doses) plus bNAbs (two infusion doses), after which ART was discontinued” has now been corrected, to read “In the second of two macaque studies, sixteen animals were treated with N-803 (six weekly doses) plus bNAbs (three infusion doses), after which ART was discontinued.”

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