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Hematopoietic stem cell transplantation for adults with EBV-positive T- or NK-cell lymphoproliferative disorders: efficacy and predictive markers

Bone Marrow Transplantation volume 51, pages 879–882 (2016)Cite this article

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EBV-positive T- or natural killer (NK)-cell lymphoproliferative disorders (EBV-T/NK-LPDs) comprise chronic active EBV disease (CAEBV), severe mosquito bite allergy (sMBA) and hydroa vacciniforme (HV). These disorders are accompanied by clonally proliferating EBV-infected T or NK cells in the peripheral blood (PB) or lesions.1 Furthermore, they gradually progress, resulting in fatal T- or NK-cell lymphoma or hemophagocytic lymphohistiocytosis (HLH).2 Therefore, they were recently classified as T- or NK-cell neoplasms by the World Health Organization (2008).3

EBV-T/NK-LPDs are resistant to chemotherapy. Patients who were treated with allogeneic hematopoietic stem cell transplantation (HSCT) had a significantly better prognosis than those not treated with HSCT.4, 5 However, the effects have been mainly investigated in children. Furthermore, the optimal time for HSCT administration and the prognostic factors have not been determined. Here we conducted a retrospective analysis of adult patients with EBV-T/NK-LPDs who underwent allogeneic HSCT to address these issues.

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Authors and Affiliations

  1. Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan

    A Arai, C Sakashita, M Yamamoto, M Jinta & O Miura

  2. Department of Nephrology, Tomei Atsugi Hospital, Kanagawa, Japan

    C Hirose

  3. Division of Advanced Medicine for Virus Infections, National Research Institute for Child Health and Development, Tokyo, Japan

    K-I Imadome

  4. Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan

    S Fujiwara

  5. Clinical Research Center, Medical Hospital of Tokyo Medical and Dental University, Tokyo, Japan

    M Tomita

  6. Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    N Shimizu

  7. Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan

    T Morio

Authors
  1. A Arai
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  2. C Sakashita
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  7. S Fujiwara
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  11. O Miura
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Correspondence to A Arai.

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Arai, A., Sakashita, C., Hirose, C. et al. Hematopoietic stem cell transplantation for adults with EBV-positive T- or NK-cell lymphoproliferative disorders: efficacy and predictive markers. Bone Marrow Transplant 51, 879–882 (2016). https://doi.org/10.1038/bmt.2016.3

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