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Cryopreservation as a way to maintain extracorporeal photopheresis regimen for GvHD treatment while circumventing patient temporary inability to undergo apheresis

Bone Marrow Transplantation volume 52, pages 167–170 (2017)Cite this article

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Extracorporeal photopheresis (ECP) is a safe treatment in patients with mild acute or chronic GvHD.1, 2, 3 However, its clinical use is sometimes limited by logistical problems that compromise repeated aphereses, especially venous access failure.

Merlin et al.4 previously concluded that cryopreservation before irradiation did not impair WBC functional capabilities. The hematopoietic stem cell transplantation (HSCT) centers of Nancy and Clermont-Ferrand (CF) University Hospitals investigated the use of frozen and thawed WBC (FTWBC, ‘cryo-ECP’) in a series of GvHD patients.

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References

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Authors and Affiliations

  1. Department of Hematology, Allogeneic Hematopoietic Stem Cell Transplantation Unit, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France

    C Pochon, L Clément, D Michel, A Perrot, G Roth-Guépin & M Detrait

  2. Department of Cell Therapy, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France

    L Reppel, V Décot & D Bensoussan

  3. Department of Cell Therapy, Cell Therapy Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France

    P Halle & J Kanold

  4. Department of Paediatric Anaesthesia, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France

    A Zang

  5. Department of Paediatric Clinical Research, INSERM CIC-1405, Clermont-Ferrand, France

    J Kanold, N Rouel & E Merlin

  6. Department of Therapeutic Hemapheresis, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France

    B Donzé & S Mathieu-Nafissi

Authors
  1. C Pochon
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  2. L Reppel
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  5. L Clément
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  6. D Michel
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  7. A Perrot
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  8. G Roth-Guépin
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  9. M Detrait
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  12. B Donzé
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  13. V Décot
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  14. S Mathieu-Nafissi
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  15. E Merlin
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  16. D Bensoussan
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Correspondence to C Pochon.

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Pochon, C., Reppel, L., Halle, P. et al. Cryopreservation as a way to maintain extracorporeal photopheresis regimen for GvHD treatment while circumventing patient temporary inability to undergo apheresis. Bone Marrow Transplant 52, 167–170 (2017). https://doi.org/10.1038/bmt.2016.240

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