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Low bone mineral density in adolescents with leukemia after hematopoietic stem cell transplantation: prolonged steroid therapy for GvHD and endocrinopathy after hematopoietic stem cell transplantation might be major concerns?

Bone Marrow Transplantation volume 52, pages 144–146 (2017)Cite this article

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Hematopoietic stem cell transplantation (HSCT) has become an important therapeutic modality for leukemia. However, this treatment has significant adverse effects on the endocrine system, including bone health.1 The amount of bone gained during puberty is the main contributor to peak bone mass, which is a major determinant of osteoporosis and fracture risk in the elderly.2 Patients who do not reach the optimal bone mineral density (BMD) during childhood, particularly during adolescence, might be more likely to suffer from osteoporotic fractures later in life.3

International Society for Clinical Densitometry Pediatric Official Positions recommends a bone densitometric assessment in diseases secondary to cancer or therapies with adverse effects on bone health.4 However, limited data about assessment of osteoporosis in adolescents with leukemia after HSCT are available. In this study, we aim to investigate the reduced bone mass and endocrinopathy/treatment factors associated with low BMD in adolescents >14 years with hematologic malignancy after HSCT using a Korean BMD reference.5, 6

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Authors and Affiliations

  1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    W K Cho, M B Ahn, J-W Lee, N-G Chung, M H Jung, B Cho & B-K Suh

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  1. W K Cho
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  2. M B Ahn
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Correspondence to N-G Chung or B-K Suh.

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Cho, W., Ahn, M., Lee, JW. et al. Low bone mineral density in adolescents with leukemia after hematopoietic stem cell transplantation: prolonged steroid therapy for GvHD and endocrinopathy after hematopoietic stem cell transplantation might be major concerns?. Bone Marrow Transplant 52, 144–146 (2017). https://doi.org/10.1038/bmt.2016.199

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