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Acute pericarditis before engraftment in hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 51, pages 459–461 (2016)Cite this article

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Although allogeneic hematopoietic stem cell transplantation (HSCT) can be curative for various hematological disorders, it continues to be associated with a significant incidence of treatment-related death. Cardiac complications during or immediately after HSCT are rare and potentially life-threatening.1, 2 Moreover, the influence of each cardiac complication on HSCT-related outcomes remains unclear. Therefore, we conducted a single-center retrospective study to examine patients who developed acute pericarditis before engraftment in HSCT.

We included 464 adult patients (⩾16 years old) who underwent HSCT between 1995 and 2014 at The University of Tokyo Hospital, Japan. Of these, 284 patients were males (61.2%) and the median age was 42 years. Acute myeloid leukemia (n=160) was the most common condition followed by acute lymphoblastic leukemia (n=94), chronic myeloid leukemia (n=59), lymphoma (n=56), myelodysplastic syndrome (n=53) and other diseases (n=42). In total, 352 patients (75.9%) received conventional myeloablative conditioning (MAC) regimens comprising the following: (i) 120 mg/kg of cyclophosphamide (Cy)+12 Gy of TBI, (ii) 30 mg/kg of VP-16+120 mg/kg of Cy+12 Gy of TBI+6 g/m2 of AraC, (iii) 40 mg/kg of VP-16+40 mg/kg of Cy+12 Gy of TBI and (iv) 16 mg/kg oral or 12.8 mg/kg IV busulfan+120 mg/kg Cy+0 to 4 Gy of TBI. More than half of the patients received HSCT from unrelated donors (260; 56.0%), and most received HSCT from an HLA-matched donor (331; 71.3%). Regarding stem cell source, 301 patients (64.9%) received bone marrow transplantation (BMT), 122 patients received PBSCs (26.3%), and the other patients received cord blood (8.8%).

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References

  1. Tichelli A, Bhatia S, Socie G . Cardiac and cardiovascular consequences after haematopoietic stem cell transplantation. Br J Haematol 2008; 142: 11–26.

    Article  Google Scholar 

  2. Murdych T, Weisdorf DJ . Serious cardiac complications during bone marrow transplantation at the University of Minnesota, 1977-1997. Bone Marrow Transplant 2001; 28: 283–287.

    Article  CAS  Google Scholar 

  3. Kupari M, Volin L, Suokas A, Timonen T, Hekali P, Ruutu T . Cardiac involvement in bone marrow transplantation: electrocardiographic changes, arrhythmias, heart failure and autopsy findings. Bone Marrow Transplant 1990; 5: 91–98.

    CAS  PubMed  Google Scholar 

  4. Braverman AC, Antin JH, Plappert MT, Cook EF, Lee RT . Cyclophosphamide cardiotoxicity in bone marrow transplantation: a prospective evaluation of new dosing regimens. J Clin Oncol 1991; 9: 1215–1223.

    Article  CAS  Google Scholar 

  5. Schaumann R, Ponisch W, Helbig JH, Hegenbart U, Ackermann G, Hofmann J et al. Pericarditis after allogeneic peripheral blood stem cell transplantation caused by Legionella pneumophila (non-serogroup 1). Infection 2001; 29: 51–53.

    Article  CAS  Google Scholar 

  6. Russo RL, Dulley FL, Suganuma L, Franca IL, Yasuda MA, Costa SF . Tuberculosis in hematopoietic stem cell transplant patients: case report and review of the literature. Int J Infect Dis 2010; 14: e187–e191.

    Article  Google Scholar 

  7. Sagrista-Sauleda J, Angel J, Sanchez A, Permanyer-Miralda G, Soler-Soler J . Effusive-constrictive pericarditis. N Engl J Med 2004; 350: 469–475.

    Article  CAS  Google Scholar 

  8. Imazio M, Brucato A, Belli R, Forno D, Ferro S, Trinchero R et al. Colchicine for the prevention of pericarditis: what we know and what we do not know in 2014 - systematic review and meta-analysis. J Cardiovasc Med (Hagerstown) 2014; 15: 840–846.

    Article  CAS  Google Scholar 

  9. Morley-Smith AC, Cowie MR, Vazir A . Pericardial constriction attributable to graft-versus-host disease: importance of early immunosuppression. Circ Heart Fail 2013; 6: e59–e61.

    Article  Google Scholar 

  10. Rackley C, Schultz KR, Goldman FD, Chan KW, Serrano A, Hulse JE et al. Cardiac manifestations of graft-versus-host disease. Biol Blood Marrow Transplant 2005; 11: 773–780.

    Article  Google Scholar 

  11. Liu YC, Gau JP, Hong YC, Yu YB, Hsiao LT, Liu JH et al. Large pericardial effusion as a life-threatening complication after hematopoietic stem cell transplantation-association with chronic GVHD in late-onset adult patients. Ann Hematol 2012; 91: 1953–1958.

    Article  Google Scholar 

  12. Norkin M, Ratanatharathorn V, Ayash L, Abidi MH, Al-Kadhimi Z, Lum LG et al. Large pericardial effusion as a complication in adults undergoing SCT. Bone Marrow Transplant 2011; 46: 1353–1356.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by JPSS KAKENHI Grant Number 26463337.

Author contributions

AS designed the study, prepared the data, performed the analysis, interpreted the data and wrote the manuscript; AH, AN, KT, AT, SH, YK, TK, SY, KU, FN and YN prepared the data and reviewed the manuscript; MK designed the study, interpreted the data and wrote the manuscript.

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  1. A Shinohara

    Present address: Department of Hematology, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan.,

Authors and Affiliations

  1. Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    A Shinohara, A Honda, A Nukina, K Takaoka, A Tsukamoto, S Hangai, Y Kogure, T Kobayashi, S Yamazaki, K Ueda, F Nakamura, Y Nannya & M Kurokawa

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  1. A Shinohara
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  2. A Honda
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Corresponding author

Correspondence to M Kurokawa.

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The authors declare no conflict of interest.

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Shinohara, A., Honda, A., Nukina, A. et al. Acute pericarditis before engraftment in hematopoietic stem cell transplantation. Bone Marrow Transplant 51, 459–461 (2016). https://doi.org/10.1038/bmt.2015.282

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