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Post-transplant Events

New-onset microalbuminuria following allogeneic myeloablative SCT is a sign of near-term decrease in renal function

Bone Marrow Transplantation volume 48, pages 972–976 (2013)Cite this article

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Abstract

The emergence of microalbuminuria following conditioning chemotherapy may predict the development of renal dysfunction. To confirm this, a 1-year retrospective cohort study was conducted in 31 myeloablative allogeneic SCT patients who received five consecutive measurements of albuminuria before conditioning therapy and on days 0, 7, 14 and 28 following SCT. The cohort had neither microalbuminuria nor renal dysfunction at baseline. Microalbuminuria was defined as an albumin–creatinine (Cr) ratio over 30 mg/g, and renal dysfunction was as an estimated glomerular filtration rate <60 mL/min per 1.73 m2. Cumulative incidence of renal dysfunction over time was analyzed by the Kaplan–Meier method. Multivariate Cox proportional hazards analysis was used to examine an association of de novo microalbuminuria with the incidence of renal dysfunction. In all, 16 patients (52%) developed microalbuminuria that was positive at least two times among the four measurements after SCT. The actuarial occurrence of chronic kidney disease was significantly higher in patients who developed microalbuminuria than in those who did not. Incidence of microalbuminuria had a significant risk of subsequent renal dysfunction (hazard ratio (95% confidence interval), 7.3 (1.2–140)). In conclusion, de novo microalbuminuria following conditioning therapy is a warning of near-term loss of renal function.

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Acknowledgements

We thank Drs Noriko Doki and Manabu Oshikawa for their invaluable participation in this study.

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Authors and Affiliations

  1. Department of Medicine, Division of Nephrology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

    T Morito & M Ando

  2. Department IV of Internal Medicine, Tokyo Women’s Medical University, Tokyo, Japan

    T Morito, M Ando, K Tsuchiya & K Nitta

  3. Department of Medicine, Division of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

    T Kobayashi, K Kakihana, K Ohashi, H Akiyama & H Sakamaki

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  1. T Morito
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  8. K Nitta
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  9. H Sakamaki
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Correspondence to M Ando.

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Morito, T., Ando, M., Kobayashi, T. et al. New-onset microalbuminuria following allogeneic myeloablative SCT is a sign of near-term decrease in renal function. Bone Marrow Transplant 48, 972–976 (2013). https://doi.org/10.1038/bmt.2012.271

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